Hu X

Abstract Objective To identify risk factors for postoperative pelvic–abdominal infection after total laparoscopic hysterectomy in patients with benign gynecological diseases and to develop and validate a clinically applicable prediction m…

BACKGROUND: Aspartame, a widely used artificial sweetener, has been implicated in multiple toxicities. However, its potential reproductive toxicity mechanisms remain unclear. This study aimed to investigate the underlying relationship betwe…

BackgroundStandardized residency training in obstetrics and gynecology (OB/GYN) relies heavily on Case-Based Learning (CBL). Yet, manually curating high-quality teaching cases remains a labor-intensive burden.ObjectiveTo develop and evaluat…

ObjectiveTo evaluate the clinical efficacy of Xiaonang Yusi decoction (XNYSD, ) in patients with phlegm-dampness type polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET), and to investigate its un…

BackgroundOver 2.5 million cycles in vitro fertilization (IVF) are conducted annually, and numbers are expected to rise with the aging population. The controlled ovarian stimulation (COS) process, key to IVF success, is inherently complex. …

Endometrial receptivity is essential for implantation and pregnancy, yet the role of the m6A demethylase FTO remains unclear. We examined epithelial Fto and Wnt signaling during the implantation window using CRISPR/Cas9 Fto knockout mice an…

Hydrogels are highly hydrated three-dimensional polymeric network materials that have attracted considerable attention in medical and biomedical fields owing to their favorable chemical modifiability, physical tunability, biocompatibility, …

Per- and polyfluoroalkyl substances (PFAS) are a class of anthropogenic organic compounds ubiquitous in the environment. Growing evidence has underscored these associated health risks. Diminished ovarian reserve (DOR), which is characterize…

Blood-based liquid biopsies hold transformative potential for non-invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating…

Mechanical loading is a defining feature of pregnancy, yet its integration with ion-channel physiology in the myometrium remains incompletely synthesized. This Review examines how uterine stretch, overdistension, oxytocin-associated signali…

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

In brief: We present the first single-cell transcriptomic atlas of follicular fluid from an ovarian endometrioma (OMA) patient, revealing a novel TCR+ macrophage subtype, aberrant granulosa cell developmental trajectories, immune dysregulat…

BACKGROUND: Multiple myeloma (MM) in association with pregnancy is a rare event, and a consensus is lacking. It is urgent to increase the awareness of investigations required for a suspected diagnosis of MM during pregnancy and optimise its…

ObjectiveThis work aimed to evaluate the clinical value of serumanti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and transvaginal ultrasound (TVU) parameters in the diagnosis of ovarian reserve fun…

AIM: Adenomyosis and endometriosis are gynecological conditions with overlapping symptoms but distinct pathologies. Both affect the women's reproductive system, but their interrelation and shared clinical pathways are underexplored. This st…

PURPOSE: Endometriosis (EMS) is a chronic gynecological disorder with unclear pathogenesis. While the vaginal and gut microbiomes are known to influence EMS, few studies have analyzed both microbiomes integrally. This study aims to characte…

ObjectiveTo develop and validate a diagnostic nomogram model for predicting atypical endometrial hyperplasia (AEH) and endometrial carcinoma (EC) in women aged 40-60 years with abnormal uterine bleeding (AUB), incorporating detailed bleedin…

Study questionWhat are the impacts of different male infertility factors on embryological, cumulative pregnancy and neonatal outcomes of IVF/ICSI cycles?Summary answerSome severe male infertility factors, i.e. severe oligoasthenozoospermia …

BackgroundThis phase 2 trial comprised dose exploration (stage 1) and dose confirmation stages (stage 2) to determine the safety and efficacy of HSK21542 in patients undergoing laparoscopic abdominal surgery.MethodsIn stage 1, patients were…

OBJECTIVE: To systematically evaluate the efficacy and safety of Chinese herbal medicine (CHM) for endometriosis-associated pain (EAP). METHODS: Randomized controlled trials (RCTs) were retrieved from PubMed, Embase, and Cochrane Library u…

Adenomyosis, characterized by clinical intractability, significantly impacts female fertility and life quality due to the absence of definitive diagnostic markers and effective treatment options. The invagination theory is a primary hypothe…

IntroductionOptimal luteal phase support (LPS) is essential for successful embryo transfer. In our previous study, we found that LPS combined with Gushen Antai pill (GSATP) could significantly improve ongoing pregnancy rate (OPR) and reduce…

ObjectiveTo develop a predictive tool in the form of a Nomogram based on the Cox regression model, which incorporates the impact of the length of treatment cycles on the outcome of live birth, to evaluate the probability of infertile couple…