Jukka‐Pekka Mecklin

ORCID: 0000-0003-4895-2249 · 3 papers in corpus
article 2017
Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study
Molecular and clinical oncology ·doi:10.3892/mco.2017.1211

Data available on lifestyle-associated hormonal and medical factors among endometrial cancer (EC)-affected women who carry the Lynch Syndrome (LS) mutation is limited. The aim of the present retrospective case study was to compare the repro…

2016
Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.
British journal of cancer ·doi:10.1038/bjc.2016.193

BackgroundLynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients.MethodsThe study cohort included 136 LS mutation-positive women.…

2014
Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation.
Epigenetics ·doi:10.4161/15592294.2014.983374

Diagnosis and treatment of epithelial ovarian cancer is challenging due to the poor understanding of the pathogenesis of the disease. Our aim was to investigate epigenetic mechanisms in ovarian tumorigenesis and, especially, whether tumors …