Liu Y

Endometriosis (EMs) is a chronic inflammatory disorder featured by infertility and pain. The role of N6-methyladenosine (m6A) in EMs has been evidenced. This study investigated the molecular mechanism of METTL14-m6A-KLF4 modulating macropha…

The glucose metabolism homeostasis in the follicular fluid microenvironment plays an important role in follicular maturation and ovulation, and excessively high or low glucose concentrations have adverse effects on the differentiation of fo…

PURPOSE: Exploration of the location of sacral injuries following ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for uterine fibroids and analysis of its influencing factors. METHODS: A retrospective analysis was co…

The incidence and mortality rates of liver cancer in China remain elevated. Although early-stage liver cancer is amenable to surgical resection, a significant proportion of patients are diagnosed at advanced stages. Currently, in addition t…

OBJECTIVE: Effective early diagnosis and timely intervention in acute pancreatitis (AP) are essential for improving patient outcomes. This study aims to evaluate the clinical utility of the neutrophil CD64 index (nCD64) in stratifying patie…

Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. Ho…

Quantitative real-time PCR (qRT-PCR), western blotting, and immunohistochemical (IHC) staining were used to assess the expression of NLRC3 in tissues and cells. The effects of NLRC3 on the proliferation, apoptosis, migration, and invasion o…

BACKGROUND AND OBJECTIVE: Minimally invasive endometriosis surgery can be done laparoscopically or with robotic assistance. The choice of modality of this procedure could impact postprocedure pain levels and the need for opioids to manage p…

This study investigates the role of paraneoplastic Ma antigen 5 (PNMA 5), a member of the PNMA family of proteins, in ovarian endometriosis (EM). These proteins are known to play a significant role in various physiological activities and ar…

Although per- and polyfluoroalkyl substances (PFAS) exposure has been linked to endometriosis, this association remains controversial, and the underlying mechanisms are unclear. This study aimed to investigate this relationship and explore …

Endometriosis is a common gynecological disorder, whose pathogenesis remains incompletely understood. Macrophages, a key type of immune cell, are pivotal in the context of endometriosis. This study seeks to explore the interactions between …

As an emerging endocrine-disrupting agent and structural analog of bisphenol A (BPA), bisphenol B (BPB) raises significant concerns due to its potential to induce male reproductive toxicity. Despite its presence in maternal bodily fluids, t…

INTRODUCTION: Emerging evidence indicates that dysregulated palmitic acid (PA) homeostasis plays a key role in inducing lipotoxicity and cellular dysfunction in mammalian endometrial epithelial cells. While this phenomenon has been document…

BACKGROUND: Endometrial thickness measurement (EMT) is not a reliable predictor of clinical pregnancy in Asherman syndrome (AS) patients. The aim of this study is to investigate the impact of endometrial patterns on reproductive outcomes in…

Ovarian tumor (OT) is the most lethal form of gynecologic malignancy, with minimal improvements in patient outcomes over the past several decades. Metastasis is the leading cause of ovarian cancer-related deaths, yet the underlying mechanis…

BACKGROUND: This study evaluated the effectiveness of quinagolide vaginal ring on reducing total lesion size in endometrioma, deep infiltrating endometriosis (DIE), and adenomyosis, as assessed using high-resolution MRI and imaging biomarke…

BACKGROUND: Low-grade chronic inflammation is observed in women with polycystic ovary syndrome (PCOS). A recent genome-wide association study (GWAS) suggested that several inflammation marker levels were altered in the blood routine tests i…

OBJECTIVE: Surgical site infections (SSI) after hysterectomy constitute significant postoperative complications, affecting patient recovery and healthcare costs. We conducted a systematic review of risk factors for SSI in patients undergoin…

The hyaluronic acid synthase (HAS) family participates in key physiological processes such as follicular development, oocyte maturation, ovulation, and embryo implantation by regulating the synthesis of hyaluronic acid, and plays an importa…

INTRODUCTION: Recent investigations have underscored the importance of long non-coding RNAs (lncRNAs), which exhibit more specific expression in tissues and cells than mRNA and are involved in gene regulation during development, pathology, …

OBJECTIVES: To analyze clinical outcomes and the factors that influence the therapeutic outcomes of high-intensity focused ultrasound (HIFU) ablation for different types of submucosal uterine fibroids. MATERIALS AND METHODS: A total of 626…

BACKGROUND: Endometriosis (EMs) and adenomyosis (AD) are prevalent gynecological disorders with overlapping symptoms but potentially distinct pathophysiology. This study was to understand different gene expression patterns of eutopic endome…

Background & aimsIntestinal barrier dysfunction plays an important role in the development of severe acute pancreatitis (SAP). The aim of our study was to investigate the role of single immunoglobulin IL-1 receptor-related molecule (SIGIRR)…

BACKGROUND: Premature Ovarian Failure (POF) is a heterogeneous syndrome characterized by ovarian dysfunction, frequently associated with autoimmune factors. The interaction between peripheral and ovarian immune signals remains unclear. Rece…