Motati DR

ORCID: 0000-0002-4000-1548 · 1 paper in corpus

2020

Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.

Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.9b01218

Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathology in central nervous system diseases such as epilepsy, Alzheimer's disease, and cerebral aneurysms. A selective and brain-permeable EP2 antago…