Grootjans J

ORCID: 0000-0002-2805-4831 · 2 papers in corpus

2025

Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer.

Nature communications ·doi:10.1038/s41467-025-58999-6

Patients with peritoneal metastasized colorectal cancer (PM-CRC) have a dismal prognosis. We hypothesized that an immunosuppressive environment in the peritoneal cavity underlies poor prognosis. We define the composition of the human perito…

2024

T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model.

Frontiers in immunology ·doi:10.3389/fimmu.2024.1415457

BackgroundThe occurrence of peritoneal metastasis (PM) in patients with colorectal cancer (CRC) has a dismal prognosis. There is often limited response to systemic- and immunotherapy, even in microsatellite unstable (MSI) CRC. To overcome t…