Natarajan P

ORCID: 0000-0001-8402-7435 · 9 papers in corpus · active 2022-2025
2025
Nature cardiovascular research ·doi:10.1038/s44161-025-00749-4

SARS-CoV-2 infection can result in long COVID, characterized by post-acute symptoms from multiple organs. Current hypotheses on mechanisms underlying long COVID include persistent inflammation and thromboembolism; however, compelling eviden…

2025
Nature cardiovascular research ·doi:10.1038/s44161-025-00700-7

Human genetics supports a causal involvement of IL-6 signaling in atherosclerotic cardiovascular disease, prompting the clinical development of anti-IL-6 therapies. Genetic evidence has historically focused on IL6R missense variants, but em…

2025
Current opinion in lipidology ·doi:10.1097/mol.0000000000000966

Purpose of reviewThis review highlights contributions of the Global Lipids Genetics Consortium (GLGC) in advancing the understanding of the genetic etiology of blood lipid traits, including total cholesterol, LDL cholesterol, HDL cholestero…

2024
Nature reviews. Nephrology ·doi:10.1038/s41581-023-00778-x

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a sizeable proportion of an individual's circulating blood cells are derived from a single mutated haematopoietic stem cell. CHIP occurs frequently w…

2024
Cureus ·doi:10.7759/cureus.70632

BackgroundMüllerian anomalies significantly impact female reproductive health. This study aims to compare the diagnostic efficacy of three-dimensional ultrasound (3D-US) and magnetic resonance imaging (MRI) in detecting and classifying thes…

2024
Cureus ·doi:10.7759/cureus.62111

BackgroundEndometrial cancer (EC) is the most common gynecological malignancy. Accurate preoperative staging is essential for guiding treatment. The depth of myometrial invasion is a key prognostic factor. This prospective study aimed to ev…

2024
Nature reviews. Genetics ·doi:10.1038/s41576-024-00709-x

Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present from conception, but they vary between individuals and accumulate over generations. By contra…

2023
Journal of the American College of Cardiology ·doi:10.1016/j.jacc.2023.06.045

Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary athe…

2022
Cells ·doi:10.3390/cells11111828

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popula…