Ashina M

ORCID: 0000-0003-0951-5804 · 4 papers in corpus
2026
Plasma CGRP Levels in Migraine: A Registry for Migraine Study.
Neurology ·doi:10.1212/wnl.0000000000218152

Background and objectivesCalcitonin gene-related peptide (CGRP) plays a central mechanistic role in migraine and is an established drug target. However, it remains unclear whether peripheral plasma CGRP levels meaningfully reflect disease a…

2025
Hallmarks of primary headache: part 3 - cluster headache.
The journal of headache and pain ·doi:10.1186/s10194-025-02145-6

BackgroundCluster headache (CH) is a rare primary headache disorder characterized by recurrent episodes of strictly unilateral excruciating pain accompanied by trigemino-autonomic signs, which significantly impacts the quality of life, soci…

2021
Efficacy and safety of fremanezumab in patients with episodic and chronic migraine with documented inadequate response to 2 to 4 classes of migraine preventive medications over 6 months of treatment in the phase 3b FOCUS study.
The journal of headache and pain ·doi:10.1186/s10194-021-01279-7

BackgroundFremanezumab, a fully humanized monoclonal antibody (IgG2Δa) selectively targets the calcitonin gene-related peptide and has proven efficacy for the preventive treatment of migraine. In this study, we evaluated the long-term effic…

2017
Calcitonin gene-related peptide and pain: a systematic review.
The journal of headache and pain ·doi:10.1186/s10194-017-0741-2

BackgroundCalcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiolog…