Charles R. Long — Endo Lab

lab-animal 2023

Hexavalent Chromium Disrupts Oocyte Development in Rats by Elevating Oxidative Stress, DNA Double-Strand Breaks, Microtubule Disruption, and Aberrant Segregation of Chromosomes

International journal of molecular sciences ·doi:10.3390/ijms241210003

Environmental and occupational exposure to hexavalent chromium, Cr(VI), causes female reproductive failures and infertility. Cr(VI) is used in more than 50 industries and is a group A carcinogen, mutagenic and teratogenic, and a male and fe…

lab-animal 2015

Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1507931112

Endometriosis is a debilitating, estrogen-dependent, progesterone-resistant, inflammatory gynecological disease of reproductive age women. Two major clinical symptoms of endometriosis are chronic intolerable pelvic pain and subfertility or …

lab-animal 2012

Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Growth of Experimental Endometriosis in Nude Mice Evaluated by Real-time Noninvasive Imaging and Fluorescence Microscopy.

·doi:10.1093/biolreprod/87.s1.550

Endometriosis is a highly prevalent estrogen-dependent gynecological inflammatory disease of reproductive-age women characterized by the presence of functional endometrial cells outside the uterus commonly leading to inflammation, pain and …