Lynnette A. Ruiz

High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, reported to be elevated in h…

UnlabelledLysyl oxidases (LOXs) are enzymes involved in collagen deposition, extracellular membrane remodeling, and invasive/metastatic potential. Previous studies reveal an association of LOXs and endometriosis. We aimed to identify the me…

This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like pr…

Endometriosis is considered a multifactorial disease influenced by genetic predisposition, deficient immune system and environmental factors. The most common symptoms are chronic pelvic pain and infertility. The pathophysiological mechanism…

Endometriosis is associated with activation of local and systemic inflammatory mechanisms, including increased levels of chemokines and other proinflammatory cytokines. We have previously reported increased gene expression of chemokine rece…

Endometriosis is a gynecological disease characterized by the presence of stroma and epithelial cells outside the uterine cavity, causing pain and infertility. This disease is estrogen-dependent and is associated with the activation of infl…

OBJECTIVE: To validate a rat model of endometriosis using complimentary DNA (cDNA) microarrays by identifying common gene expression patterns between experimental and natural disease. DESIGN: Autotransplantation rat model. SETTING: Medica…

Endometriosis is a common, incurable gynecologic disease of unknown etiology, which causes incapacitating pain during menses and infertility. There are no specific non-invasive diagnostic tests for endometriosis, therefore diagnosis is curr…