Uterine leiomyomas (uterine fibroids) are sex-steroid dependent benign tumors. Limited knowledge is available regarding the role of estrogen and their receptors in the regulation of fibroids in premenopausal women, and in their shrinkage af…
ObjectiveTo compare the mechanisms for cervical ripening after treatment with prostaglandin E2 or antiprogestin (RU486) to spontaneous cervical ripening, with focus on gonadal steroid receptors.Study designCervical biopsies were obtained fr…
OBJECTIVE: To determine whether gonadal steroids and insulin-like growth factor I influence the final cervical remodeling during parturition. METHODS: Cervical biopsies were obtained transvaginally before labor (n = 10) and after spontaneou…
The interrelationship between estrogen and insulin-like growth factor-I (IGF-I) in the regulation of uterine growth was studied in the rat. The levels of the estrogen receptor (ER), ER mRNA, and IGF-I mRNA in rat uterus and liver were monit…