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BACKGROUND: Leukocytospermia (LCS) is commonly identified during male infertility evaluation and is associated with impaired semen quality. However, the specific roles of various inflammatory conditions in LCS remain incompletely understood…

OBJECTIVE: To develop and validate a prediction model for uterine fibroid risk based on clinical characteristics and blood biochemical indicators, and to explore its risk factors and clinical application value. METHODS: This retrospective c…

The inherent perception of lactate as the byproduct of glycolysis has been transformed by the discovery of lysine lactylation (Kla). Lactylation modification, a reversible and precise acylation, occurs on both histones and non-histone prote…

BACKGROUND: Deeply infiltrating endometriosis (DIE), characterized by its extrauterine invasion, is strongly associated with chronic pelvic pain (CPP). Peripheral-central sensitization synergistically contribute to the pathogenesis of CPP i…

PURPOSE: The growing antimicrobial resistance in Neisseria gonorrhoeae (N. gonorrhoeae) complicates the elimination of gonococcal infections and increases the risk of female infertility. In this study, we investigated the antimicrobial susc…

BACKGROUND: Endometriosis (EM) may be associated with adverse pregnancy outcomes, but its relationship with gestational diabetes mellitus (GDM) and circulating metabolic biomarkers remains incompletely defined. This study evaluated temporal…

The hypothalamus plays a vital role in reproductive processes. Previous studies have identified hypothalamic miRNAs involved in mammalian reproduction, but the miRNA profiles induced by photoperiod changes remain unclear. In this study, we …

BACKGROUND: Higher prepregnancy body mass index (BMI) is a well-established risk factor for adverse neonatal outcomes in IVF-conceived pregnancies; therefore, weight management is important for infertile patients, yet it remains challenging…

Knee osteoarthritis (KOA) is a highly prevalent chronic degenerative joint disorder characterized by progressive articular cartilage degeneration, chondrocyte death, and extracellular matrix degradation. Accumulating evidence indicates that…

BACKGROUND: Implantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful impla…

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder and a major cause of female infertility. While epigenetic dysregulation, notably DNA methylation, has been recognized as a key driver of PCOS pathogenesis, the specific involv…

PURPOSE: Circulating estrogen metabolites of the 2-, 4- or 16-hydroxyestrone (OH) pathways may be differentially associated with breast cancer risk due to varying estrogenic and genotoxic activity. However, little is known about the influen…

BACKGROUND AND AIMS: Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, an…

Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological int…

Although Müllerian adenosarcoma of the uterus shows weak malignant potential, there are still some factors indicating a worse prognosis. An incontinuous pelvic pain with urinary frequency, urgency, and hypouricemia arose in a mid-70s woman …

BACKGROUND: Vaginal lubricants are commonly used during sexual activity and clinical procedures such as transvaginal ultrasound. Epidemiologic and laboratory studies indicate hyperosmolal water-based lubricants may disrupt the vaginal micro…

BACKGROUND: Hyperosmolal lubricants may negatively affect the vaginal microenvironment, increasing the risk for bacterial vaginosis (BV). We compared the incidence of Amsel-defined BV in reproductive-age women exposed to hyperosmolal lubric…

OBJECTIVES: Leiomyomatosis peritonealis disseminata (LPD) is a rare and specific type of leiomyomatosis that is often misdiagnosed as malignant tumor with peritoneal metastasis, and accurate diagnosis is critical to treatment planning. The …

BACKGROUND: Infertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays a crucial role in female reproductive health. This study aimed to investiga…

BACKGROUND: Chronic pain afflicts approximately 20% of the global adult population and is frequently undertreated, with available pharmacologic options often associated with significant long-term adverse effects. Although omega-3 fatty acid…

PURPOSE: The global prevalence and trends of gynecological diseases (GDs) among women of childbearing age (WCBA) remain unclear and may be underestimated. This study aims to evaluate the prevalence of GDs at global, regional, and national l…

BACKGROUND: This study aimed to assess the evolution, trends, and research hotspots of publications related to natural killer (NK) cells and miscarriage. METHODS: The literature on NK cells and miscarriage was retrieved from the Web of Sci…

BACKGROUND: Endometriosis is a chronic inflammatory condition afflicting women of reproductive age. Our study aims to clarify the function and mechanism of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and high mobility grou…