Guo WJ

No ORCID on file · 2 papers in corpus · active 2016-2017
2017
Role of transforming growth factor β‑1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target.
International journal of molecular medicine ·doi:10.3892/ijmm.2017.3042

The present study aimed to reveal the metabolic alterations of the extracellular matrix (ECM) in uterosacral ligament (USL) with pelvic organ prolapse (POP) and to explore the role of transforming growth factor‑β1 (TGF‑β1) in pathogenesis o…

2016
Collagen metabolic disorder induced by oxidative stress in human uterosacral ligament‑derived fibroblasts: A possible pathophysiological mechanism in pelvic organ prolapse.
Molecular medicine reports ·doi:10.3892/mmr.2016.4919

Pelvic organ prolapse (POP) is a global health problem, for which the pathophysiological mechanism remains to be fully elucidated. The loss of extracellular matrix protein has been considered to be the most important molecular basis facilit…