Xiaoyong Zhu — Endo Lab

article 2025

Harnessing the CD16-PI3Kγ axis in peritoneal CD14hi macrophages: A transformative approach to endometriosis management

International journal of biological macromolecules ·doi:10.1016/j.ijbiomac.2025.146627

Endometriosis (EMS) is a prevalent estrogen-dependent gynecological disorder characterized by ectopic growth of endometrial tissue. Central to its pathophysiology, peritoneal CD14hi macrophages exhibit a pro-EMS phenotype and drive disease …

review 2023

Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives

Frontiers in immunology ·doi:10.3389/fimmu.2023.1134663

Endometriosis, an estrogen-dependent chronic inflammatory disease characterized by the growth of endometrium-like tissues outside the uterine cavity, affects 10% of reproductive-age women. Although the pathogenesis of endometriosis is uncer…

article 2018

Role of miR‑449b‑3p in endometriosis via effects on endometrial stromal cell proliferation and angiogenesis

Molecular medicine reports ·doi:10.3892/mmr.2018.9341

Endometriosis is a common gynecological disease and the pathogenesis is not clearly understood. Previous studies have demonstrated via microarray techniques that microRNA (miR)‑449b was significantly downregulated both in ectopic and eutopi…

article 2016

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis

Cell death & disease ·doi:10.1038/cddis.2016.375

Abstract Foxp3 + regulatory T (T reg ) cells contribute to the local dysfunctional immune environment in endometriosis, an estrogen-dependent gynecological disease, which affects the function of ectopic endometrial tissue clearance by the i…

article 2016

1-Methytryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis

·doi:10.1016/j.jri.2016.04.172