Giudice, Linda C

Guidance on standards of care, particularly incorporating region-specific needs, is foundational to high-quality healthcare. The availability of region-specific guidance on endometriosis care has not been documented, especially in low- and …

Additional file 1: Table S1. Samples used in the study. Endo: endometriosis; PE: proliferative; SE: secretory: MSE: mid secretory, LSE: late secretory; N/A: not applicable.

Additional file 2: Table S2. CyTOF panels used in the study. Left: broad panel, right: focused panel.

Additional file 3: Fig. S1. Manual gating strategy for the focused panel. The figure shows an example of the dot plots obtained using FlowJo in endometrial cells.

Additional file 3: Fig. S1. Manual gating strategy for the focused panel. The figure shows an example of the dot plots obtained using FlowJo in endometrial cells.

Additional file 4: Fig. S2. Endometrial sampling methods. A) The figure shows UMAPs of the two methods used for endometrial tissue collection, biopsy (red) and hysterectomy (blue). The left panel shows a UMAP with the overlap between the tw…

Additional file 4: Fig. S2. Endometrial sampling methods. A) The figure shows UMAPs of the two methods used for endometrial tissue collection, biopsy (red) and hysterectomy (blue). The left panel shows a UMAP with the overlap between the tw…

Additional file 5: Fig. S3. Batch effects derived from different runs. The figure shows UMAPs representing the distribution of the cells from the runs in the CyTOF instrument for both endometrium (top panel) and PBMCs (bottom panel). The fi…

Additional file 5: Fig. S3. Batch effects derived from different runs. The figure shows UMAPs representing the distribution of the cells from the runs in the CyTOF instrument for both endometrium (top panel) and PBMCs (bottom panel). The fi…

Additional file 6: Fig. S4. Proportion of endometrial immune populations identified by using the broad panel. The figure shows the proportion of each population in the ring graphs and the percentage of each population is also shown in each …

Additional file 6: Fig. S4. Proportion of endometrial immune populations identified by using the broad panel. The figure shows the proportion of each population in the ring graphs and the percentage of each population is also shown in each …

Additional file 7: Fig. S5. Fluctuation of all endometrial immune populations identified in the broad panel. A) Differences in abundance of populations throughout the menstrual cycle in control samples. B) Differences in abundance of popula…

Additional file 7: Fig. S5. Fluctuation of all endometrial immune populations identified in the broad panel. A) Differences in abundance of populations throughout the menstrual cycle in control samples. B) Differences in abundance of popula…

Additional file 8: Fig. S6. Fluctuation of all endometrial immune populations identified in the focused panel. A) Differences in abundance of populations throughout the menstrual cycle in control samples. B) Differences in abundance of popu…

Additional file 8: Fig. S6. Fluctuation of all endometrial immune populations identified in the focused panel. A) Differences in abundance of populations throughout the menstrual cycle in control samples. B) Differences in abundance of popu…

Additional file 9: Table S3. Expression of the significant markers between endometriosis and controls in all cell types in endometriosis versus controls from the focused panel. Significant values are highlighted in grey. Endo: endometriosis…

Abstract Background Endometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and infertility. Immune dysfunction includes insufficient immune lesion clearance, a pr…

Abstract Background Endometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and infertility. Immune dysfunction includes insufficient immune lesion clearance, a pr…

Programmed cellular responses to cycling ovarian-derived steroid hormones are central to normal endometrial function. Abnormalities therein, as in the estrogen-dependent, progesterone-"resistant" disorder, endometriosis, predispose to infer…

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and wa…

Krüppel-like Factor (KLF) 13 and the closely related KLF9 are members of the Sp/KLF family of transcription factors that have collectively emerged as essential regulators of tissue development, differentiation, proliferation, and programmed…