Tianyuan Wang

No ORCID on file · 9 papers in corpus · active 2020-2024

Study types

  • article 1
  • other 1

Condition tags

  • endometriosis 1
  • infertility 1
other 2024
Nature communications ·doi:10.1038/s41467-024-46180-4

Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums fo…

2022
Cells ·doi:10.3390/cells11111760

For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding ch…

2022
Endocrinology ·doi:10.1210/endocr/bqac116

Endometrial health is affected by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor α (ESR1) cistromes and transcriptomes of endometrial biopsi…

2022
F&S science ·doi:10.1016/j.xfss.2022.09.001

ObjectiveTo systematically analyze the cell composition and transcriptome of primary human endometrial stromal cells (HESCs) and transformed human endometrial stromal cells (THESCs).DesignThe primary HESCs from 3 different donors and 1 immo…

article 2021
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgab381

CONTEXT: Suboptimal endometrial thickening is associated with lower pregnancy rates and occurs in some infertile women treated with clomiphene. OBJECTIVE: To examine cellular and molecular differences in the endometrium of women with subopt…

2020
Science signaling ·doi:10.1126/scisignal.aaz9646

Differences in the relative abundances of the progesterone receptor (PGR) isoforms PGRA and PGRB are often observed in women with reproductive tract cancers. To assess the importance of the PGR isoform ratio in the maintenance of the reprod…

2020
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgz117

ContextPoor uterine receptivity is one major factor leading to pregnancy loss and infertility. Understanding the molecular events governing successful implantation is hence critical in combating infertility.ObjectiveTo define Progesterone R…

2020
·doi:10.1101/2020.03.27.012039

WNK1 is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans which is associated with abnormal ion homeostasis. Our earlier findings demonstrated that WNK1 is cr…

2020
JCI insight ·doi:10.1172/jci.insight.141832

WNK1 (with no lysine [K] kinase 1) is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans, which is associated with abnormal ion homeostasis. WNK1 is critical f…