Takao Hinoi

ORCID: 0000-0003-0462-6177 · 1 paper in corpus
other 2020
Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer
Cancer science ·doi:10.1111/cas.14558

BRAFV600E mutation accounts for up to 90% of all BRAF mutations in human colorectal cancer (CRC), and constitutively activates the MEK-MAPK pathway. It is recognized that neutralizing mAbs for epidermal growth factor receptor alone are not …