Liu D

OBJECTIVES: The research aims to leverage machine learning techniques to better understand the diagnosis of myofascial pelvic pain syndrome (MPPS) and to develop useful tools for clinical practice. METHODS: This study retrospectively analy…

OBJECTIVE: The study aims to elucidate the factors associated with the short-term efficacy of ovarian vein embolization (OVE) in the treatment of pelvic venous insufficiency (PVI), to construct a predictive model for short-term efficacy of …

BACKGROUND: This study systematically investigated phenotypes causally associated with Alzheimer's disease (AD) across the phenome and validated the findings at cognitive and neuroimaging levels using real-world clinical data. METHODS: We …

BACKGROUND: Sperm DNA fragmentation index (DFI) has emerged as a potential marker of male fertility, but its clinical value in assisted reproductive technology (ART) remains debated. This study aimed to investigate the association between s…

BACKGROUND: Ultrasound-based deep learning (DL) models for the precise diagnosis of endometrial cancer are insufficient. Our aim is to develop and validate an automatic multi-modal ultrasound DL prediction model for the accurate identificat…

BACKGROUND Vitamin D is crucial for overall health. While prenatal deficiency is linked to poor obstetric outcomes, its preconception levels are less studied. This investigation sought to characterize the distribution and influencing factor…

Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent estrogen-dependent gynecological disorder with limited therapeutic efficacy and high recurrence rates. Ferroptosis-an iron-dependent, non-apop…

Fibroblast growth factor receptor 2 (FGFR2) has emerged as a highly promising therapeutic target due to its critical role in the pathogenesis and progression of endometriosis. To date, a variety of FGFR2 inhibitors have exhibited remarkable…

BACKGROUND: IL20RB, interleukin 20 receptor subunit beta, functions as a cytokine receptor subunit coding gene and has been discovered to serve an essential function in human malignancies. However, the link between IL20RB expression, clinic…

This study evaluates the synergistic therapeutic effect of metformin (MET) combined with medroxyprogesterone acetate (MPA) on endometriosis (EM) and investigates the involvement of the steroid receptor coactivator-1 (SRC-1) and mitogen-indu…

BACKGROUND: Hydrosalpinx affects 10-30% of infertile women, creating a hostile tubal microenvironment that impairs embryonic development. Although fluid embryotoxicity is recognised, specific toxic metabolites and their molecular mechanisms…

RESEARCH QUESTION: Is there a relationship between the location of adenomyosis lesions and obstetric and neonatal outcomes? DESIGN: A total of 466 women diagnosed with adenomyosis via transvaginal ultrasound between January 2019 and Decemb…

INTRODUCTION: Pulmonary endometriosis (PE) is an unusual cause of catamenial hemoptysis, with only a small proportion of endometriosis cases involving the thorax. Standard management often involves surgical resection combined with hormonal …

Introduction: Pulmonary endometriosis (PE) is an unusual cause of catamenial hemoptysis, with only a small proportion of endometriosis cases involving the thorax. Standard management often involves surgical resection combined with hormonal …

Introduction: Pulmonary endometriosis (PE) is an unusual cause of catamenial hemoptysis, with only a small proportion of endometriosis cases involving the thorax. Standard management often involves surgical resection combined with hormonal …

Background and Objective: The ultrasound sliding sign dynamically assesses pouch of Douglas (POD) obliteration in suspected endometriosis. Transvaginal (TVS) and transrectal (TRS) ultrasound are used in patients with and without a self-repo…

Endometrial immune disorders create an inhospitable endometrial environment for embryonic nidation in endometriosis. CD8 + tissue resident memory T cells (CD8 +TRM) are abundant tissue resident immune cells in endometrium, but the effect of…

BACKGROUND: Endometriosis is a chronic, heterogeneous disease with limited non-hormonal treatment options. Drug repurposing provides an accelerated route to identify safe, tolerable, and potentially effective therapies for endometriosis. Re…

Gynecological diseases (GyD) are related to reproductive tissue disorders such as the cervix, vagina, fallopian tubes, and ovaries, which can affect fertility. Among these diseases, we can mention endometriosis, ovarian laziness, primary ov…

BACKGROUND: Adenomyosis is thought to be associated with adverse perinatal outcomes. This study aimed to assess the relationship between pre-pregnancy uterine volume and preterm birth in singleton gravid women with adenomyosis. METHODS: We…

OBJECTIVE: Limited evidence exists on the safety of inactivated COVID-19 vaccines and the optimal vaccination timing for women undergoing in vitro fertilization-frozen embryo transfer (IVF-FET). This study aims to examine the associations b…

BACKGROUND: Myofascial pelvic pain syndrome (MPPS) is a common but often underdiagnosed cause of chronic pelvic pain in women, significantly affecting quality of life. Early and accurate identification of patients at risk is essential for i…

OBJECTIVE: The purpose of this study was to compare oral estradiol valerate and estradiol transdermal gel for clinical pregnancy outcomes in patients undergoing frozen-thaw embryo transfer (FET). METHODS: This was a prospective study perfo…

Chronic widespread pain (CWP) remains challenging due to its heterogeneous causes and complex mechanisms. A total of 2920 plasma proteins are analyzed from 29,254 UK Biobank participants. A total of 256 proteins are identified as cross-sect…

Disulfidptosis is a pathologic process that occurs under conditions of NADPH deficiency and excess disulfide bonds in cells that express high levels of SLC7A11. This process is caused by glucose deprivation-induced disulfide stress and was …