Xin Zhen

ORCID: 0000-0002-8419-1961 · 8 papers in corpus · active 2013-2024

Study types

  • other 4
  • article 2
  • preprint 2

Condition tags

  • endometriosis 5
  • infertility 5
  • adenomyosis 2
other 2024
Role of PRMT5 mediated HOXA10 arginine 337 methylation in endometrial epithelial cell receptivity
Biochemical and biophysical research communications ·doi:10.1016/j.bbrc.2024.151004

A successful embryo implantation relies heavily on the receptivity of the endometrial epithelium, a process regulated by various molecular mechanisms. Evaluating endometrial receptivity in infertility patients undergoing assisted reproducti…

article 2022
Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1
Biology of reproduction ·doi:10.1093/biolre/ioac041

Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in EMs. Whether CAPN7 a…

other 2022
Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis
Cell death discovery ·doi:10.1038/s41420-022-01196-x

Decidualization is a prerequisite for successful embryo implantation, in which elongated fibroblast-like endometrial stromal cells differentiate into more rounded decidual cells. Accumulating evidence has stressed the important role of the …

preprint 2022
Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis
·doi:10.21203/rs.3.rs-1800392/v1
preprint 2021
Calpain7 Negatively Regulates Human Endometrial Stromal Cell Decidualization in Endometriosis by Promoting FoxO1’s Phosphorylation and Nuclear Exclusion via Hydrolyzing AKT1
·doi:10.21203/rs.3.rs-985926/v1

Abstract Background Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in …

other 2019
miR-21 reverses impaired decidualization through modulation of KLF12 and NR4A1 expression in human endometrial stromal cells†
Biology of reproduction ·doi:10.1093/biolre/ioz026

Impaired decidualization has been considered a major cause of infertility in adenomyosis. However, the mechanism remains poorly understood. Recent studies suggest that microRNAs (miRNA) play a crucial role in embryo implantation. The aim of…

article 2015
MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12
·doi:10.1186/s12958-015-0019-y

BACKGROUND: The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we ex…

other 2013
PCAF impairs endometrial receptivity and embryo implantation by down-regulating β3-integrin expression via HOXA10 acetylation
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2013-1429

BACKGROUND: Homeobox A10 (HOXA10), a key transcription factor, plays a critical role in endometrial receptivity by regulating the expression of downstream target genes, such as β3-integrin (ITGB3), but little is understood about the mechani…