David Llobet‐Navàs

2026

ARID1A deficiency reprograms the tumor secretome, enhancing microenvironmental remodeling and metastatic dissemination in endometrial carcinoma.

Cell death & disease ·doi:10.1038/s41419-026-08723-z

Loss-of-function mutations in AT-rich interactive domain-containing protein 1 A (ARID1A), accompanied by reduced protein expression, are common in endometrial carcinoma (EC) and correlate with shorter progression-free survival. Alterations …

review 2025

Dysregulated autophagy in endometriosis: molecular mechanisms, controversies, and clinical implications

Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-025-01494-w

Endometriosis is one of the most common gynecological diseases in women and is still one of the most understudied diseases, affecting the daily lives of patients. Although the exact cause of this condition remains unclear, autophagy has bee…

2025

Endometrial cancer progression driven by PTEN-deficiency requires miR-424(322)~503.

Cell death & disease ·doi:10.1038/s41419-025-08022-z

Endometrial cancer is the most frequent type of cancer in the female reproductive tract. Loss-of-function alterations in PTEN, leading to enhanced PI3K/AKT activation, are among the most frequent molecular alterations in endometrial cancer.…

2017

Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.

Autophagy ·doi:10.1080/15548627.2016.1271512

Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease relapse. Dissecting a…