Antonius ter Laak

ORCID: 0000-0003-1820-002X · 2 papers in corpus · active 2019

Study types

  • article 2

Condition tags

  • mesh:D004715 2
  • endometriosis 2
  • chronic_pelvic_pain 1
article 2019
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis
Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2019.07.007
article 2019
Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.8b01862

The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes-the latter being frequently associated with severe, acute, and chronic p…