Vogel SN

ORCID: 0000-0001-8244-2555 · 1 paper in corpus

2012

The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.1200202

Asp(299)Gly (D299G) and, to a lesser extent, Thr(399)Ile (T399I) TLR4 polymorphisms have been associated with gram-negative sepsis and other infectious diseases, but the mechanisms by which they affect TLR4 signaling are unclear. In this st…