David W. Erikson — Endo Lab

article 2016

Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis

ObjectiveAdenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysregulation of genes and pathways in eutopic end…

article 2016

Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719116650758

ObjectiveAdenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysregulation of genes and pathways in eutopic end…

article 2016

Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis1

Biology of reproduction ·doi:10.1095/biolreprod.115.136010

Human endometrium undergoes cyclic regeneration involving stem/progenitor cells, but the role of resident endometrial mesenchymal stem cells (eMSC) as progenitors of endometrial stromal fibroblasts (eSF) has not been definitively demonstrat…

article 2014

Inhibition of epidermal growth factor receptor restores decidualization markers in stromal fibroblasts from women with endometriosis

·doi:10.5301/je.5000198

Purpose Decidualization comprises specific biochemical and morphological changes in uterine endometrium essential for establishment of pregnancy. This process is abnormal in women with endometriosis, a disorder in which endometrial-like tis…