Oskari Heikinheimo

BACKGROUND: Understanding of the impact of endometriosis on adverse early pregnancy outcomes has evolved in recent decades and has been partly attributed to endocrine dysfunction and chronic inflammation. However, data from population-based…

OBJECTIVE: To study first birth rates according to endometriosis subtype after surgical diagnosis among nulliparous women. DESIGN: Retrospective population-based cohort study using Finnish national registers, linking women with first surgi…

This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis. A retrospective register-based cohort study identified women with a first sur…

This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis. A retrospective register-based cohort study identified women with a first sur…

OBJECTIVE: This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis. METHOD: A retrospective register-based cohort study identified wo…

BACKGROUND: Ovarian endometriosis is one of the most frequently diagnosed endometriosis subtypes. Surgical treatment may be required in selected cases, and indications for surgery have evolved over the years. However, recurrence is common a…

STUDY QUESTION: How does the burden of somatic disorders compare between women with surgically verified endometriosis diagnosed in adolescence or early adulthood, and matched women without a history of endometriosis? SUMMARY ANSWER: Women …

INTRODUCTION: The use of combined oral contraceptives (COCs), but not of progestin-only pills (POPs) is associated with an increased risk of cardiovascular events. A detailed examination of how different oral contraceptives impact the metab…

INTRODUCTION: Endometriosis is associated with educational and occupational challenges, including absenteeism and reduced capacity to study and work. We aimed to investigate long-term educational and occupational outcomes among women diagno…

INTRODUCTION: Endometriosis is associated with pain and infertility. However, little is known about birth rate among women with endometriosis on population level. We studied whether women with endometriosis have lower birth rate than women …

CONTEXT: Use of a levonorgestrel-releasing intrauterine device (LNG-IUD) has become common irrespective of age and parity. To date, only a few studies have examined its possible metabolic changes and large-scale biomarker profiles in detail…

BACKGROUND: Psychosocial aspects underlie and maintain persistent pain. Emotions have emerged as a target for psychological interventions in pain management. Our aim was to better understand the relationship between emotions and bodily sens…

BACKGROUND: Endometriosis diagnosed in adults is associated with increased risk of various psychiatric disorders. However, little is known concerning psychiatric comorbidity and mortality due to external causes associated with endometriosis…

STUDY QUESTION: Do women with endometriosis have lower first live birth rate before surgical diagnosis than women without verified endometriosis? SUMMARY ANSWER: Compared to reference women, the incidence of first live birth was lower in w…

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

STUDY QUESTION: How should endometriosis be diagnosed and managed based on the best available evidence from published literature? SUMMARY ANSWER: The current guideline provides 109 recommendations on diagnosis, treatments for pain and infe…

CONTEXT: Limited studies have compared the effects of combined oral contraceptives (COCs) containing natural estrogens and synthetic ethinylestradiol (EE) on reproductive hormones. OBJECTIVE: To compare estradiol valerate (EV) + dienogest …

STUDY QUESTION: Does an estradiol-based combined oral contraceptive (COC) have a milder effect on the serum proteome than an ethinylestradiol (EE)-based COC or dienogest (DNG) only? SUMMARY ANSWER: The changes in serum proteome were multif…

Louis Marcellin, MD, PhD; Francois Goffinet, MD, PhD; Elie Azria, MD, PhD; Anne Thomin, MD; Charles Garabedian, MD, PhD; Jeanne Sibiude, MD, PhD; Eric Verspyck, MD, PhD; Martin Koskas, MD, PhD; Pietro Santulli, MD, PhD; Jessica Rousseau, Ph…

INTRODUCTION: Increasing awareness of endometriosis in adolescents requires data on the nature of the disease and its management. Our objective was to investigate the subtypes of surgically confirmed endometriosis in adolescents (aged <20 y…

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Peer reviewed

Background Endometriosis is associated with increased risk of clear cell ovarian cancer and has even suggested being an etiological factor for this cancer. Association between endometriosis and extraovarian clear cell cancers is unclear. Th…

BACKGROUND: Endometriosis is associated with increased risk of clear cell ovarian cancer and has even suggested being an etiological factor for this cancer. Association between endometriosis and extraovarian clear cell cancers is unclear. T…

INTRODUCTION: Progestogens (progestins) are widely used for contraception, in postmenopausal hormone therapy, and in treatment of abnormal uterine bleeding and endometriosis. Norethisterone (NET) and its acetate (NETA) differ from other pro…