Tsai-der Chuang

No ORCID on file · 9 papers in corpus
lab-animal 2026
Transcriptomic and functional analysis of fibroid extracellular vesicles
Clinical science (London, England : 1979) ·doi:10.1042/cs20250814

Exosomes were isolated from cultures of fibroid explants and matched myometrial explants, and their RNA cargo was analyzed by next-generation sequencing to profile both long and short RNA species. Fibroid-derived exosomes (Fib-EXO) expresse…

observational 2024
The immune landscape of uterine fibroids as determined by mass cytometry
F&S science ·doi:10.1016/j.xfss.2024.06.004

OBJECTIVE: To study the differences in immune cell profiles in uterine fibroids (Fibs) and matched myometrium (Myo). DESIGN: Observational study. SETTING: Laboratory study. PATIENT(S): The study included tissue that was collected from 10…

lab-animal 2022
Further characterization of tryptophan metabolism and its dysregulation in fibroids
F&S science ·doi:10.1016/j.xfss.2022.04.005

OBJECTIVE: To determine the expression of enzymes in tryptophan (Trp) catabolism in fibroids and matched myometrium and determine the effects of race and mediator complex subunit 12 gene (MED12) mutation on their expression. DESIGN: Experi…

other 2019
Cross-talk between miR-29c and transforming growth factor-β3 is mediated by an epigenetic mechanism in leiomyoma
Fertility and sterility ·doi:10.1016/j.fertnstert.2019.07.1324

OBJECTIVE: To determine the expression of miR-29c and its target gene transforming growth factor-β3 (TGF-β3) in leiomyoma and the mechanisms of their reciprocal regulation. DESIGN: Experimental study. SETTING: Academic research laboratory…

2016
Endometrial miR-200c is Altered During Transformation into Cancerous States and Targets the Expression of ZEBs,

A number of microRNAs (miRNAs), including miR-200 family, are aberrantly expressed in endometriosis and endometrial cancer. Hereweassessed theexpression and functional aspectsofmiR-200c inendometrial tissues (N 52) fromnormal endometrial bi…

2016
Original Articles Endometrial miR-200c is Altered During Transformation into Cancerous States and Targets the Expression of ZEBs,

A number of microRNAs (miRNAs), including miR-200 family, are aberrantly expressed in endometriosis and endometrial cancer. Hereweassessed theexpression and functional aspectsofmiR-200c inendometrial tissues (N 52) fromnormal endometrial bi…

lab-animal 2014
miR-200c regulates IL8 expression by targeting IKBKB: a potential mediator of inflammation in leiomyoma pathogenesis
PloS one ·doi:10.1371/journal.pone.0095370

We have previously reported that leiomyoma expressed lower levels of miR-200c and elevated IL8 as compared to paired myometrium. Here we addressed the regulatory functions of miR-200c on the expression of inflammatory mediators and cellular…

other 2012
Endometrial miR-181a and miR-98 expression is altered during transition from normal into cancerous state and target PGR, PGRMC1, CYP19A1, DDX3X, and TIMP3
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2012-1018

CONTEXT: Evidence suggests that a number of microRNA (miRNA) are aberrantly expressed in endometrial disorders with potential posttranscriptional regulation of their specific target genes, including ovarian steroid receptors. OBJECTIVES: O…

other 2012
Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLT1, IKKβ, KLF9, and FBLN5
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719112438448

A number of microRNAs (miRNAs), including miR-200 family, are aberrantly expressed in endometriosis and endometrial cancer. Here we assessed the expression and functional aspects of miR-200c in endometrial tissues (N = 52) from normal endom…