Simonds WF

ORCID: 0000-0001-7806-706X · 5 papers in corpus
2025
Genotype-Phenotype Correlations in the Hyperparathyroidism-Jaw Tumor Syndrome.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgae909

Establishing genotype-phenotype correlations in disorders of hereditary endocrine neoplasia is important for clinical screening, genetic counseling, prognostication, surveillance, and surgical strategy, and may also provide clues about dise…

2023
Molecular and Clinical Spectrum of Primary Hyperparathyroidism.
Endocrine Reviews ·doi:10.1210/endrev/bnad009

Recent data suggest an increase in the overall incidence of parathyroid disorders, with primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is associated with morbidities (fractures, kidney stones, chronic…

2023
Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgad368

ContextHyperparathyroidism-jaw tumor (HPT-JT) syndrome is a heritable form of primary hyperparathyroidism caused by germline inactivating mutations in CDC73 encoding parafibromin and is associated with an increased risk of parathyroid cance…

2021
Familial Hyperparathyroidism.
Frontiers in endocrinology ·doi:10.3389/fendo.2021.623667

Regulation of the serum calcium level in humans is achieved by the endocrine action of parathyroid glands working in concert with vitamin D and a set of critical target cells and tissues including osteoblasts, osteoclasts, the renal tubules…

2012
Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome.
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.08.017

ObjectiveTo describe the clinical management of menorrhagia in a woman with hyperparathyroidism-jaw tumor syndrome (HPT-JT).DesignCase report.SettingLarge translation research hospital.Patient(s)A 26-year-old nulligravid woman with familial…