Aya Shirafuji

No ORCID on file · 3 papers in corpus
article 2026
Negative impacts of ovarian endometrioma on preantral follicle development: implications for endometriosis-related infertility
Frontiers in endocrinology ·doi:10.3389/fendo.2026.1679042

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disorder and a leading cause of female infertility. Ovarian endometriomas, a common manifestation of endometriosis, are commonly associated with diminished ovarian func…

other 2025
Pro-inflammatory cytokines disrupt in vitro preantral follicle development by targeting granulosa and theca cell functions
Frontiers in endocrinology ·doi:10.3389/fendo.2025.1667019

BACKGROUND: Chronic low-grade inflammation is increasingly recognized as a contributing factor to female infertility. Elevated levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 are observed in ovarian conditions including …

review 2023
Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1324429

The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular de…