Liu S

RATIONALE: The accurate classification of retroperitoneal neoplasms remains challenging, particularly when distinguishing between epithelioid leiomyoma and perivascular epitheloid cell tumor (PEComa) due to significant histological and immu…

OBJECTIVE: Systemic inflammatory response plays a key role in the pathogenesis of endometriosis. This study aimed to investigate the association between the aggregate index of systemic inflammation (AISI), defined as neutrophil count × plat…

ObjectivesThis study aimed to examine the associations between shift work and menstrual disorders among female nurses and to explore the potential mediating role of sleep quality in these relationships.MethodsA cross-sectional study was con…

Infertility is a prevalent clinical issue which disrupts normal human life and exerts an impact on fertility rates within the population. The increase in environmental pollutants, including acetyl tributyl citrate (ATBC), has given rise to …

BACKGROUND: CLEC5A (C-type lectin domain family 5 member A) is an innate immune receptor implicated in inflammatory signaling, contributing to hyperinflammatory responses in infections and sterile inflammation. However, CLEC5A dynamics in h…

BACKGROUND: In mammals, precise regulation of primordial follicle activation is essential for maintaining the female reproductive lifespan. In this study, we demonstrated that the vitamin D receptor (VDR) is expressed in both pre-granulosa …

Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin-dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S-phase entry. In a …

Female infertility, accounting for 40–50% of infertility cases globally, underscores the urgent need for non-invasive biomarkers to guide early intervention. Cell-free DNA (cfDNA)—released via apoptosis, necrosis, or active secretion—has em…

OBJECTIVE: To explore the effect of laparoscopic ovarian cystectomy on ovarian reserve function and its related risk factors. METHODS: The clinical data of 150 patients with unilateral ovarian cysts admitted to our hospital were retrospect…

BACKGROUND: Pelvic floor myofascial pain (PFMP) is an important yet often overlooked cause of chronic pelvic pain (CPP). The currently available diagnostic methods are limited due to issues such as insufficient efficacy and difficulties in …

BACKGROUND: Effective individualized tools to predict cumulative live birth rates are lacking for patients with ovarian endometriomas undergoing In Vitro Fertilization or Intracytoplasmic Sperm Injection after ultrasound-guided ethanol scle…

A teenage girl presented with sudden lower abdominal pain following exercise, prompting initial consideration of ovarian cyst rupture by the attending emergency physician. However, the presence of unilateral renal absence on Computed Tomogr…

BackgroundOvarian cancer (OC) remains highly lethal due to frequent late-stage diagnosis and the challenge of distinguishing malignant from benign adnexal masses (BAM) preoperatively. Reliable non-invasive diagnostic biomarkers remain an un…

INTRODUCTION: The objective of this study was to examine the impact of semaphorin 3F (SEMA3F) on the proliferation, migration and ferroptosis of endometrial stromal cells in patients with endometriosis (EMS). METHODS: This study collected …

INTRODUCTION: PCOS is the most common disorder encompassing reproductive, metabolic, and endocrine abnormalities, and has an increased risk of adverse pregnancy and neonatal complications, such as miscarriage, gestational diabetes mellitus,…

This study explored the genetic evidence linking triglyceride-related pathways and lipid-lowering drug targets with endometriosis risk and investigated the genetic association between TG levels and EM. Using genome-wide association study (G…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease characterized by tumor-like growth behavior and limited therapeutic options. Increasing evidence suggests that gut microbiota may contribute to EMs progression by promoting c…

Ovarian cancer remains a major global health burden among women, ranking eighth in both cancer incidence and cancer mortality worldwide in 2024, with an estimated 330,731 new cases and 203,850 deaths. Epithelial ovarian cancer (EOC) account…

Endometriosis is an estrogen-dependent disorder characterized by chronic inflammation, immune dysregulation, and altered hormone metabolism. Although gut microbiota-derived metabolites have been implicated in shaping immune microenvironment…

Ovarian disorders such as polycystic ovary syndrome (PCOS) and primary ovarian insufficiency (POI) have complex etiologies that are difficult to disentangle using observational studies. Mendelian randomization (MR) offers a powerful approac…

Pelvic inflammatory disease (PID) is a condition caused by the ascension of pathogenic microorganisms from the lower genital tract to the uterus and/or fallopian tubes, and is one of the most common clinical syndromes among women of reprodu…

BACKGROUND: Salpingitis is a leading cause of female infertility and ectopic pregnancy worldwide. Despite advances in reproductive medicine, its early diagnosis and effective prevention of long-term sequelae remain challenging due to its of…

BACKGROUND: Endometriosis (EM) is a chronic inflammatory gynaecological disorder affecting approximately 10% of women of reproductive age. Early diagnosis remains challenging because definitive diagnosis still relies on invasive surgical co…