Hamersma H

No ORCID on file · 2 papers in corpus · active 2008-2012

Study types

  • other 1

Condition tags

  • endometriosis 1
2012
X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids.
The Journal of biological chemistry ·doi:10.1074/jbc.m111.308403

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecular mechanisms. The structure of Asoprisnil bound to the agoni…

other 2008
11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists
Bioorganic & medicinal chemistry ·doi:10.1016/j.bmc.2008.01.010

Recently, a new class (often referred to as SPRMs: selective progesterone receptor modulators) of progesterone receptor ligands with mixed agonist/antagonist properties has been described. Such compounds are envisaged, for example, as treat…