Kanako Hayashi

ORCID: 0000-0002-5028-799X · 14 papers in corpus · active 2016-2026

Study types

  • article 6
  • other 6
  • preprint 1
  • review 1

Condition tags

  • endometriosis 14
  • chronic_pelvic_pain 7
  • mesh:D004715 6
  • infertility 5
  • adenomyosis 2
  • dyspareunia 1
  • mesh:D017699 1
  • mesh:D004716 1
  • endometrioma 1
  • dysmenorrhea 1
other 2026
bioRxiv : the preprint server for biology ·doi:10.64898/2026.02.06.704463

Endometriosis is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, non-hormonal therapies is urgently needed. We previously reported t…

other 2026
The Journal of clinical investigation ·doi:10.1172/JCI194136

This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an underlying m…

other 2026
Biology of reproduction ·doi:10.1093/biolre/ioag082

Endocrine-disrupting chemicals (EDCs) are a global concern for human health and the environment. EDCs include plasticizers, pharmaceutical agents, industrial chemicals, fungicides, and pesticides. Thus, EDC exposure is a manmade consequence…

other 2025
bioRxiv : the preprint server for biology ·doi:10.1101/2025.01.23.634555

INTRODUCTION: Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction creat…

article 2024
Frontiers in endocrinology ·doi:10.3389/fendo.2024.1336496

Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation…

other 2024
Frontiers in immunology ·doi:10.3389/fimmu.2024.1396000

Endometriosis is a chronic inflammatory disease that causes debilitating pelvic pain in women. Macrophages are considered to be key players in promoting disease progression, as abundant macrophages are present in ectopic lesions and elevate…

other 2023
bioRxiv : the preprint server for biology ·doi:10.1101/2023.11.09.566474

Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation…

preprint 2022
·doi:10.1101/2022.04.05.487220

Abstract Due to the vital roles of macrophages in the pathogenesis of endometriosis, targeting macrophages could be a new therapeutic direction. Here, we investigated the efficacy of niclosamide for the resolution of perturbed microenvironm…

article 2022
Communications biology ·doi:10.1038/s42003-022-04211-0

Due to the vital roles of macrophages in the pathogenesis of endometriosis, targeting macrophages could be a promising therapeutic direction. Here, we investigated the efficacy of niclosamide for the resolution of a perturbed microenvironme…

review 2022
Cells ·doi:10.3390/cells11040647

Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen and progesterone disrupts their complex regulatory mechanis…

article 2021
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202002541rrr

Endometriosis, a common gynecological disease, causes chronic pelvic pain and infertility in women of reproductive age. Due to the limited efficacy of current therapies, a critical need exists to develop new treatments for endometriosis. In…

article 2020
Biology of reproduction ·doi:10.1093/biolre/ioaa010

Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy of current treatment options, a critical need exists to develop new and effective treatm…

article 2018
Biology of reproduction ·doi:10.1093/biolre/ioy222

Endometriosis causes severe chronic pelvic pain and infertility. We have recently reported that niclosamide treatment reduces growth and progression of endometriosis-like lesions and inflammatory signaling (NF${\rm \small K}$B and STAT3) in…

article 2016
Biology of reproduction ·doi:10.1095/biolreprod.116.140236

Endometriosis causes severe chronic pelvic pain and infertility. Because the standard medication and surgical treatments of endometriosis show high recurrence of symptoms, it is necessary to improve current treatment options. In the initial…