OBJECTIVE: To compare endometrial stromal cell invasion from women with and without adenomyosis and the effect of myometrial cells using a three-dimensional coculture. DESIGN: Case-controlled blinded comparison. SETTING: University depart…
We previously demonstrated that in the CD-1 mouse, which exhibits a high incidence of age-related adenomyosis, neonatal exposure to tamoxifen induced premature uterine adenomyosis and was associated with abnormal development particularly of…
BACKGROUND AND AIM: To study the characteristics of the inner (IM) and outer (OM) myometrium in the presence and absence of uterine adenomyosis. METHODS: Case control blinded comparison carried out in a university department. Morphometric …
Adenomyosis uteri is defined by the presence of endometrium in the myometrium. The prevalence in asymptomatic women remains unknown. It is commonly associated with other pathologies. Hysterectomy remains the main surgical option for women w…
OBJECTIVE: To compare the value of SF36v2 versus multi-attribute utility score (MAS) for predicting treatment outcome in heavy menstrual bleeding (HMB). STUDY DESIGN: Longitudinal observational study, in an outpatient service of a large UK…
We determined the expression of oestrogen receptor (ER), progesterone receptor (PR), heat shock protein 27 (HSP27) and human beta-lactoglobulin in the endometrium under hormone replacement therapy (HRT). The immunohistochemical expression d…
We evaluated the histological features of the endometrium in relation to the bleeding pattern in a group of women receiving oral cyclical combined hormone replacement therapy (HRT), and compared the histological features with those of lutei…
The gonadomimetic steroid Tibolone, is currently widely used for the treatment of menopausal symptoms. Up to 20% of women have been reported to have episodes of bleeding whilst on therapy. We investigated 37 cases who experienced bleeding e…