Yang J

Ovarian clear cell carcinoma (OCCC) is resistant to chemotherapy, with limited treatment options for advanced and recurrent disease. The prevalence of OCCC differs by region. Assessing the expression of programmed cell death ligand 1 (PD-L1…

The article reports a case of fetal imperforate hymen diagnosed by prenatal MRI and confirmed by postnatal surgery. The pregnant woman underwent routine 37-week ultrasound examination, which revealed an enlarged fetal bladder and an abdomin…

BACKGROUND: Oil-based contrast medium in hysterosalpingography has been recommended as an approach to improve fertility in recent years. However, this approach has rarely been applied to patients with unknown recurrent implantation failure …

BACKGROUND: Adenomyosis is frequently associated with abnormal uterine bleeding (AUB) and anemia. In the setting of arterial stenosis or hypercoagulability, AUB may precipitate ischemic stroke. However, the optimal management strategy remai…

Ovarian cancer (OC) is a prevalent malignancy; however, the role of kinesin light chain 3 (KLC3) in OC remains unclear. The present study conducted a comprehensive investigation of KLC3 using bioinformatics analysis, as well as in vitro and…

Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they ofte…

BACKGROUND: Recurrent implantation failure (RIF) remains a significant barrier in assisted reproductive technology (ART), where multiple transfers of high-quality embryos fail to achieve pregnancy. While embryo-related factors have been ext…

The accelerating trend of obesity in women of childbearing age has become a significant issue in personal health, female fecundity, and offspring development. Simvastatin (SV) is a statin commonly prescribed oral agent for lipid-lowering th…

BACKGROUND: Despite epidemiological studies linking phthalates to ovarian cancer, their multi-target molecular mechanisms remain unresolved, hindering biomarker discovery and preventive strategies. This study integrates network toxicology, …

OBJECTIVE: Although immune dysregulation is implicated in the pathogenesis of endometriosis (EMs), the specific role of prostate transmembrane protein androgen induced 1 (PMEPA1) in modulating the function of regulatory T cells (Tregs) rema…

OBJECTIVE: Endometriosis (EMs) is a chronic inflammatory disease characterized by the presence of endometrial tissue in the non-uterine cavity, resulting in dysmenorrhea, pelvic pain, and infertility. Epidemiologic data have suggested the c…

OBJECTIVE: This study aimed to evaluate the effects of transcervical resection of the septum (TCRS) on reproductive outcomes in women of reproductive age with two types of uterine septa. METHODS: In this retrospective cohort study, we eval…

BACKGROUND AND OBJECTIVES: Multimorbidity is increasingly prevalent among the middle-aged population, yet it is largely often overlooked. We aimed to explore and compare the differences in multimorbidity patterns by sex and age among middle…

BACKGROUND: Multimorbidity substantially increases health and economic burdens, and reduces productivity in working-age individuals. We conducted a study using data from 393,170 working-age inpatients (18-59 years) in Shaanxi, China, collec…

BACKGROUND: Adenomyosis is a common gynaecological condition where ectopic endometrial glands and stroma grow within the myometrium. This condition has a high clinical burden impacting those afflicted with debilitating symptoms including he…

Intrauterine adhesions (IUA), characterized by endometrial fibrosis, pose a serious threat to women's reproductive health, yet their molecular mechanisms remain poorly understood. Here, we use single-cell RNA sequencing (scRNA-seq) to profi…

BACKGROUND: The relationship between negative emotions and chronic respiratory diseases remains largely unexplored. In this study, we employ Mendelian Randomization (MR) to investigate the potential causal relationship between negative emot…

This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveil…

BACKGROUND: The objective of this study was to assess the trade-off between cycle continuation and cancellation in slow ovarian response (SOR) patients, and to evaluate the impact of SOR on embryo developmental potential and clinical pregna…

BACKGROUND: Infertility poses a significant burden on both global and national scales. However, the epidemiology of primary infertility among reproductive-aged couples in China remains poorly understood. Therefore, this study aimed to inves…

BACKGROUND: Endometriosis and breast cancer are significant global health burdens affecting women worldwide. Both conditions share notable characteristics including estrogen dependence, progressive growth patterns, recurrence tendencies, an…

In the face of declining global birth rates, women's health status remains a critical yet often overlooked determinant. This review summarises evidence on how various aspects of women's health, including nutrition and lifestyle, socioeconom…

ETHNOPHARMACOLOGICAL RELEVANCE: The rhizome of Curcuma phaeocaulis Valeton, Curcuma wenyujin Y.H. Chen & C. Ling, or Curcuma kwangsiensis S. G. Lee et C. F. Liang, commonly known as Wen-E-Zhu and E'zhu, has been utilized in traditional Chin…

OBJECTIVE: Gonadotropin-releasing hormone agonists (GnRHa), combined with other auxiliary treatments, can improve pregnancy outcomes in in vitro fertilization-embryo transfer (IVF-ET). This research investigated the effect of acupuncture co…

BACKGROUND: Endometriosis is a common chronic gynecological condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to chronic inflammation, pelvic nodules and masses, pelvic pain, and infertility. …