Clarke IJ

ORCID: 0000-0002-6613-2757 · 2 papers in corpus · active 2009-2015

Study types

  • other 2

Condition tags

  • endometriosis 2
other 2015
The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle
Endocrinology ·doi:10.1210/en.2015-1409

Women's health disorders such as uterine fibroids and endometriosis are currently treated by GnRH modulators that effectively suppress the hypothalamic-pituitary-gonadal axis. The neurokinin-3 receptor (NK3R) is an alternative target with a…

other 2009
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
The Journal of neuroscience : the official journal of the Society for Neuroscience ·doi:10.1523/JNEUROSCI.5740-08.2009

Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common pathway by which the brain regulates reproduction. GnRH neurons are regulated by an afferent network of kisspeptin-producing neurons. Kisspeptin binds to its co…