John R. Thompson — Endo Lab

2021

Polygenic basis and biomedical consequences of telomere length variation.

Nature genetics ·doi:10.1038/s41588-021-00944-6

Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify causal link…

article 2006

Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell

·doi:10.1093/molehr/gal014

Matrix metalloproteinases (MMP) are considered to be of critical importance in the initiation of menstruation where MMP protein levels are reciprocally modulated by the actions of the gonadal steroid hormones, estradiol (E(2)) and progester…

article 2000

The effect of submucous fibroids on the dose‐dependent modulation of uterine bleeding by trimegestone in postmenopausal women treated with hormone replacement therapy

·doi:10.1111/j.1471-0528.2000.tb13227.x

OBJECTIVE: To assess the value of identifying endometrial structural abnormalities at baseline hysteroscopy in predicting the pattern of bleeding in postmenopausal women treated with hormone replacement therapy. DESIGN: A randomised, double…