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目的 基于网络药理学并运用分子对接和动物实验进行验证,平冲降逆方治疗子宫内膜异作症(EMs)的潜在分子机制。 方法 借助TCMSP和BATMAN-TCM 数据库检索平冲降逆方活性成分和作用靶点,并构建“中药-活性成分-靶点”网络。以“endometriosis”为关键词在 Genecards、OMIM和TTD数据库获取疾病靶点。将交集靶点导入 STRING 数据库和 Cytoscape 软件筛选核心治疗靶点,借助 DAVID 数据库进行GO富集分析和KEGG富集分析。利…
ETHNOPHARMACOLOGICAL RELEVANCE: Pingchong Jiangni recipe (PJR) is a Chinese herbal formula that has been used clinically for decades in the treatment of endometriosis, with effects such as shrinking the lesions and reducing the recurrence r…
BACKGROUND: Endometriosis is a chronic gynecological disease that is characterized by the presence of endometrial tissue outside the uterine cavity. The main symptoms include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. …
Endometriosis is a common gynecological condition in childbearing age women and its therapy in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine (CHM), was shown to be clinically…