Dhakal P

No ORCID on file · 5 papers in corpus · active 2014-2023
2023
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2316410120

The uterus is vital for successful reproduction in mammals, and two different types of epithelia (luminal and glandular) are essential for embryo implantation and pregnancy establishment. However, the essential cellular and molecular factor…

2021
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2026804118

Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes to offspring susceptibility to chronic adult-onset disorders. However, our understanding of the biochemical composition and mechanisms underpinning …

2019
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1915389116

The human endometrium is essential in providing the site for implantation and maintaining the growth and survival of the conceptus. An unreceptive endometrium and disrupted maternal-conceptus interactions can cause infertility due to pregna…

2015
Endocrinology ·doi:10.1210/en.2015-1397

In this report, we investigated the consequences of neonatal progesterone exposure on adult rat uterine function. Female pups were subcutaneously injected with vehicle or progesterone from postnatal days 3 to 9. Early progesterone exposure …

2014
Endocrinology ·doi:10.1210/en.2013-2150

Estrogens play pivotal roles in development and function of many organ systems, including the reproductive system. We have generated estrogen receptor 1 (Esr1)-knockout rats using zinc finger nuclease (ZFN) genome targeting. mRNAs encoding …