BACKGROUND & AIMS: Loss of AT-rich interactive domain-containing protein 1A (ARID1A) fosters acinar-to-ductal metaplasia (ADM) and pancreatic carcinogenesis by down-regulating transcription programs controlling acinar cell identity. However…
BACKGROUND: Aldo-keto reductase 1B10 (AKR1B10) is a secretory protein that is upregulated in breast cancer. OBJECTIVE: This case-controlled pilot study evaluated the serum level of AKR1B10 in healthy women and patients with a localized or …
BACKGROUND: The effect of GuizhiFuling Wan (GFW) on adenomyosis (AM) is definite. This study aimed to explore the mechanism and key therapeutic targets of GFW in treating AM through network pharmacology combined with molecular docking and e…
BACKGROUND: Atypical polypoid adenomyoma (APA) is a rare intrauterine polypoid lesion that occurs predominantly in premenopausal women. Although APA was previously considered a benign lesion and treated conservatively, an increasing number …
Endometrial diseases, including uterine fibroids, polyps, intrauterine adhesion, endometritis, etc., are the major causes of infertility among women. However, the association between essential trace element status in women and the risk of e…
BACKGROUND: Endometriosis affects up to 10 % of women of reproductive age and can lead to infertility. Research investigating whether combined exposure to arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) is related to an increased ris…
BACKGROUND: Ovarian malignant mesoderm mixed tumor (OMMMT) is a rare clinical entity. To provide reference for the treatment and prognosis of OMMMT, we analyzed the clinical features, pathology and molecular biology characteristic of publis…
Some of the key steps in adenomyosis (AM) are the migration and invasion of adenomyosis derived cells (AMDC); these processes require rearrangement of the cytoskeleton which Rho/ROCK signaling pathway is involved. The aim of the current stu…
Additional file 1: Figure S1. HE staining and QC. (A) Samples from the AM_CTRL, AM_EM and AM_EC groups were HE stained, and the black arrow shows the gland invading the muscular layer. (B) X axis represents the number of UMI in each cell, a…
Additional file 1: Figure S1. HE staining and QC. (A) Samples from the AM_CTRL, AM_EM and AM_EC groups were HE stained, and the black arrow shows the gland invading the muscular layer. (B) X axis represents the number of UMI in each cell, a…
Additional file 2: Table S1. Doublet score and predicted doublets.
Additional file 2: Table S1. Doublet score and predicted doublets.
Additional file 3: Table S2. DEGs of AM_EC vs. AM_EM (all cell types).
Additional file 3: Table S2. DEGs of AM_EC vs. AM_EM (all cell types).
Additional file 4: Table S3. Coexisting genes in Venn.
Additional file 4: Table S3. Coexisting genes in Venn.
Additional file 5: Table S4. DEGs of AM_EC vs. AM_EM (epithelial cells).
Additional file 5: Table S4. DEGs of AM_EC vs. AM_EM (epithelial cells).
Additional file 6: Table S5. Clinical characteristics of AM patients and hysteromyoma samples used in this study.
Additional file 6: Table S5. Clinical characteristics of AM patients and hysteromyoma samples used in this study.
BACKGROUND: Epidemiological studies have shown that young women often suffer from primary dysmenorrhea (PD) which is a common cause that affects their routine work and quality of life. Chinese herbal medicine has been widely used for PD in …
BACKGROUND: Adenomyosis (AM) is a common benign chronic gynaecological disorder; however, the precise pathogenesis of adenomyosis is still poorly understood. Single-cell RNA sequencing (scRNA-seq) can uncover rare subpopulations, explore ge…
Abstract Background Adenomyosis (AM) is a common benign chronic gynaecological disorder; however, the precise pathogenesis of adenomyosis is still poorly understood. Single-cell RNA sequencing (scRNA-seq) can uncover rare subpopulations, ex…
Abstract Background Adenomyosis (AM) is a common benign chronic gynaecological disorder; however, the precise pathogenesis of adenomyosis is still poorly understood. Single-cell RNA sequencing (scRNA-seq) can uncover rare subpopulations, ex…
Endometriosis (EMs) is recorded as Zheng Jia in traditional Chinese medicine (TCM) books. Guizhi Fuling Pills (GFPs), a classic prescription for promoting blood circulation and removing blood stasis, is widely used for women's blood stasis …