Kenji Unno

ORCID: 0000-0002-5590-1485 · 2 papers in corpus

article 2017

The allosteric AKT inhibitor, MK2206, decreases tumor growth and invasion in patient derived xenografts of endometrial cancer

Cancer biology & therapy ·doi:10.1080/15384047.2017.1281496

The purpose of this study was to test the effect of MK2206, an allosteric inhibitor of AKT, on the growth and invasion of patient-derived xenografts (PDX) of endometrial cancer. Three PDX lines, USC1 (uterine serous), EEC2 (endometrioid gra…

other 2013

Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2013-1661

CONTEXT: Endometriosis is characterized by progesterone resistance and hyperactivity of the AKT and MAPK pathways. Kinases can cause posttranslational modifications of the progesterone receptor (PR) to influence cellular localization and pr…