Mrinmoy Sarkar

ORCID: 0000-0002-6798-8979 · 1 paper in corpus

2023

Inhibition of DNA polymerase eta-mediated translesion DNA synthesis by small molecule sensitizes ovarian cancer stem-like cells to chemotherapy

·doi:10.21203/rs.3.rs-3118868/v1

Abstract Chemoresistance and tumor relapse pose significant challenges in achieving successful chemotherapy outcomes. Targeting DNA polymerase eta (Pol ƞ) mediated-mutagenic translesion DNA synthesis (TLS) has emerged as a promising strate…