Wang Y

Endometriosis is a debilitating, estrogen-dependent gynecological disorder characterized by profound diagnostic delays due to clinical reliance on invasive laparoscopy. Developing noninvasive, point-of-care biomarker assessment remains a cr…

Endometriosis is a prevalent gynecological disorder characterized by ectopic growth of endometrial-like tissue, often causing chronic pain, infertility, and systemic inflammation. Accurate detection and complete surgical resection remain ch…

LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in fav…

Monkeypox virus (MPXV) infection-associated intestinal manifestations, including diarrhea and proctitis, have been frequently reported during mpox outbreaks. Here, we present clinical evidence that MPXV can directly infect the human intesti…

Stem cells, with their self-renewal and multi-lineage differentiation potential, hold promise for tissue repair and intractable diseases treatment. Yet clinical translation of stem cell therapies has long been hindered by insufficient scala…

BackgroundEarlier detection is strongly associated with increased survival for women with ovarian cancer. Unfortunately, current screening strategies, employing serial serum or ultrasound assessments, lack adequate sensitivity and specifici…

Knee osteoarthritis (KOA) is a highly prevalent chronic degenerative joint disorder characterized by progressive articular cartilage degeneration, chondrocyte death, and extracellular matrix degradation. Accumulating evidence indicates that…

ObjectiveThe aim of this study is to explore the relationship between the levels of anti-Müllerian hormone (AMH) and metabolic and reproductive outcomes across different polycystic ovary syndrome (PCOS) phenotypes.MethodsIn this retrospecti…

BackgroundBenign ovarian tumor is a common clinical gynecological disease. Bilateral salpingo-oophorectomy is currently recommended for postmenopausal benign ovarian tumor, and whether the uterus needs to be removed simultaneously is contro…

STUDY OBJECTIVE: To compare the safety and efficacy of laparoscopic versus transvaginal ethanol sclerotherapy in patients with ovarian endometriomas (OEMs). DESIGN: Preliminary retrospective cohort study. SETTING: Reproductive Medicine Re…

PURPOSE: To evaluate the safety and short-term efficacy of magnetic resonance-guided high-intensity focused ultrasound surgery (MRgFUS) for adenomyosis-associated dysmenorrhea. MATERIALS AND METHODS: This retrospective single-center cohort…

Massive abdominal wall defects resulting from radical abdominal wall endometriosis (AWE) resection present a major reconstructive challenge. This study aims to assess feasibility and short-term safety of a standardized retromuscular-onlay d…

Ultraviolet (UV) radiation is a primary environmental factor responsible for skin photodamage, and exposure to UV rays is strongly linked to a variety of skin diseases. This study examined the prophylactic and therapeutic effects of Seed Oi…

BackgroundEnvironmental exposure to trace and heavy metals may influence female fertility, yet their impact on assisted reproductive outcomes remains poorly defined. Maternal diet can potentially modulate metal-related toxicity by influenci…

BackgroundPolycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM), and the risk of PCOS increases in patients with T2DM of reproductive age. The bidirectional link between PCOS and T2DM has b…

Single-cell and spatial omics have revolutionized biomedical research by enabling high-resolution molecular profiling across cells and tissues, thereby overcoming key limitations of bulk sequencing and revealing unprecedented cellular heter…

Sleep disorders and deficiencies can up-regulate pro-inflammatory mediators, but their potential adverse impact on ovarian function remains not fully understood. In this study, we investigated the immunoregulatory mechanisms underlying slee…

BackgroundThe clinical benefit of immunotherapy in ovarian cancer (OC) remains limited. The primary reason is not simply a lack of immune activation, but rather the marked spatiotemporal heterogeneity of the tumour immune microenvironment. …

To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on network pharmacology and machine learning. The effective constituents and targets of the Guizhi…

BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare (prevalence ~ 1:2 million), devastating genetic disorder characterized by progressive heterotopic ossification. Crucially, surgical trauma is a potent trigger for cata…

IntroductionAdhesive capsulitis of the shoulder is a common shoulder disease. With the ageing population, the incidence of adhesive capsulitis has been rising year by year, posing a significant threat to the quality of life of middle-aged a…

Background: Acute cholecystitis (AC) is a common inflammatory disease of the gallbladder. Although laparoscopic cholecystectomy remains the standard treatment, gallbladder drainage may be required in patients who are unsuitable for early su…

Infertility is a complex and sensitive phenomenon experienced by many couples worldwide. Our study investigated the causal effects of 486 serum metabolites on infertility using a Mendelian randomization (MR) approach, providing insights int…

This systematic review and Bayesian network meta-analysis assessed the diagnostic accuracy of wearable digital technology (WDT) in monitoring women's fertility window compared to conventional methods. 8 databases were searched until January…