Li WC

ORCID: 0000-0002-4537-9291 · 6 papers in corpus
2023
Adaptive neuroplasticity in the default mode network contributing to absence of central sensitization in primary dysmenorrhea.
Frontiers in neuroscience ·doi:10.3389/fnins.2023.1094988

IntroductionPrimary dysmenorrhea (PDM), the most prevalent gynecological problem among women of reproductive age, presents as a regular pattern of cyclic menstrual pain. The presence or absence of central sensitization (i.e., pain hypersens…

2021
Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain.
NeuroImage. Clinical ·doi:10.1016/j.nicl.2021.102576

Primary dysmenorrhea (PDM) refers to menstrual pain of which the pathological cause(s) are unknown. This study examined the associations among BDNF Val66Met polymorphisms, menstrual pain severity, and hippocampal volume among young PDM subj…

2018
Unaltered intrinsic functional brain architecture in young women with primary dysmenorrhea.
Scientific reports ·doi:10.1038/s41598-018-30827-6

Primary dysmenorrhea (PDM), painful menstruation without organic causes, is the most prevalent gynecological problem in women of reproductive age. Dysmenorrhea later in life often co-occurs with many chronic functional pain disorders, and c…

2017
The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea.
Scientific reports ·doi:10.1038/srep39906

The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecolo…

2016
Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea.
Scientific reports ·doi:10.1038/srep24543

Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavio…

2016
The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea.
Scientific reports ·doi:10.1038/srep23639

Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of …