Brinton RD

ORCID: 0000-0001-8450-772X · 3 papers in corpus · active 2021-2026
2026
Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics.
Scientific reports ·doi:10.1038/s41598-026-47740-y

Hysterectomy is the second most common surgery among women in the United States, often performed alongside elective oophorectomy. Premenopausal bilateral oophorectomy (PO) causes abrupt endocrine disruption and has been linked to increased …

2022
Endogenous and Exogenous Estrogen Exposures: How Women's Reproductive Health Can Drive Brain Aging and Inform Alzheimer's Prevention.
Frontiers in aging neuroscience ·doi:10.3389/fnagi.2022.831807

After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease (AD), the most common cause of dementia affecting over 24 million people worldwide. The prevalence of AD is higher in women than in men, with postmen…

2021
Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.
Neuroscience and biobehavioral reviews ·doi:10.1016/j.neubiorev.2021.02.040

Brain development is a life-long process that encompasses several critical periods of transition, during which significant cognitive changes occur. Embryonic development, puberty, and reproductive senescence are all periods of transition th…