Roberto Romero

BACKGROUND: Preterm birth is the leading cause of neonatal and infant mortality worldwide. Vaginal progesterone reduces the rate of preterm birth by approximately 45% in women with a singleton gestation and a mid-trimester sonographically s…

BACKGROUND: The human endometrium undergoes repeated cycles of bleeding, inflammation, tissue breakdown, and repair. Unlike most adult tissues, which heal through fibrosis, the endometrium restores its architecture and function after menstr…

BACKGROUND: Mothers who experience major obstetrical syndromes (ie, preeclampsia, spontaneous preterm birth, fetal growth restriction, fetal death, and gestational diabetes mellitus) are at an increased risk for early death from cardiovascu…

Normal uterine function depends on cyclical regeneration and the capacity to sustain pregnancy. A cesarean incision represents an injury to this remarkable organ. Although the uterus possesses exceptional healing potential, cesarean deliver…

The aim of this study was to establish the role of thymic stromal lymphopoietin (TSLP) in the intra-amniotic host response of women with spontaneous preterm labor (sPTL) and birth. Amniotic fluid and chorioamniotic membranes (CAM) were coll…

In the post-genomic era, our understanding of the molecular regulators of physiologic and pathologic processes in pregnancy is expanding at the whole-genome level. Longitudinal changes in the known protein-coding transcriptome during normal…

Neonatal uterine bleeding (NUB) occurs in approximately 5% of newborns and is generally considered to be of little clinical significance. However, the real clinical importance of this condition and its long-term implications remain to be de…

OBJECTIVE: To investigate dynamic changes in myometrial thickness during the third stage of labor. METHODS: Myometrial thickness was measured using ultrasound at one-minute time intervals during the third stage of labor in the mid-region o…

Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation…

Sponsored by the New York Academy of Sciences and Cincinnati Children's Hospital Medical Center, with support from the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Drug Abuse (NIDA), and Life Techno…

Why do humans menstruate while most mammals do not? Here, we present our answer to this long-debated question, arguing that (i) menstruation occurs as a mechanistic consequence of hormone-induced differentiation of the endometrium (referred…

PROBLEM: CXCL6 is a potent pro-inflammatory neutrophil chemoattractant and activator whose activity during pregnancy is not well-established. The purpose of this study was to determine if CXCL6 is present in amniotic fluid (AF) and if CXCL6…