Axelrod JD

ORCID: 0000-0001-6094-7392 · 1 paper in corpus

lab-animal 2023

Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium

American journal of physiology. Lung cellular and molecular physiology ·doi:10.1152/ajplung.00382.2022

Multiciliated cell loss is a hallmark of airway epithelial remodeling in chronic inflammatory airway diseases including cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease. It disrupts mucociliary clearance, which fuels …