Karen A. Matthews

Importance: Early menarche and early menopause are associated with increased risk of cardiovascular disease (CVD) in midlife, but little is known about the association between reproductive life span and the risk of CVD. Objective: To invest…

More than 30% of women in the United States have a hysterectomy by the age of 60. A high percentage of hysterectomies (55%-80%) are accompanied by bilateral oophorectomy. Cross-sectional studies have found an association between negative mo…

OBJECTIVE: To examine whether mood symptoms increased more for women in the years after hysterectomy with or without bilateral oophorectomy relative to natural menopause. METHODS: Using data from the Study of Women's Health Across the Natio…

OBJECTIVE: Cross-sectional studies suggest an association between hysterectomy and negative affect. Using prospective data, we examined the associations of negative affect, attitudes toward aging and menopause, premenstrual symptoms, and va…