Michael S. Bloom

Abstract This small pilot feasibility study shows that reverse phase protein array (RPPA) technology is a useful tool for targeted proteomics analysis in human ovarian follicular fluid. RPPA supplements mass spectrometry approaches that are…

“Poor responders” (PR) are an important category of infertile women who experience a modest response to controlled ovarian stimulation. In this study, we evaluated response to growth hormone (GH) administration among PR patient subtypes str…

BackgroundInfertility is an important health concern worldwide. Although lifestyle habits and behaviors have been widely reported as predictors of IVF outcomes by previous studies, they have not been reported for Romanian women undergoing I…

PurposeThe purpose of the study was to determine whether diagnosis of endometriosis or endometriosis with endometrioma influences in vitro fertilization (IVF) outcomes in an ethnically diverse population.MethodsWomen undergoing a first IVF …

PurposeFollicular redox balance is likely to be important for embryo quality during in vitro fertilization (IVF), and the anti-oxidative high desity lipoprotein (HDL) particle is the sole lipoprotein measured in follicular fluid (FF). There…

PurposeA hypothesis-generating pilot study exploring associations between essential trace elements measured in follicular fluid (FF) and urine and in vitro fertilization (IVF) endpoints.MethodsWe recruited 58 women undergoing IVF between 20…

The importance of high-density lipoprotein (HDL) particle components to reproduction is increasingly recognized, including the constituent paraoxonase 1 (PON1). However, the reliability characteristics of PON1 enzymes in ovarian follicular …

ObjectiveTo assess the variability of follicular fluid (FF) high-density lipoprotein (HDL) particle components.DesignCross-sectional design with assessment using two-stage nested analysis of variance.SettingReproductive health center.Patien…

PurposeWe previously reported associations between trace concentrations of Hg, Cd and Pb in blood and urine and reproductive outcomes for women undergoing in-vitro fertilization (IVF). Here we assess measurements in single follicular fluid …

BackgroundChanges in DNA methylation may play an important role in the deleterious reproductive effects reported in association with exposure to environmental pollutants. In this pilot study, we identify candidate methylation changes associ…

BackgroundSporadic anovulation among regularly menstruating women is not well understood. It is hypothesized that cholesterol abnormalities may lead to hormone imbalances and incident anovulation. The objective was to evaluate the associati…

Trace exposures to the toxic metals mercury (Hg), cadmium (Cd) and lead (Pb) may threaten human reproductive health. The aim of this study is to generate biologically-plausible hypotheses concerning associations between Hg, Cd, and Pb and i…

PurposeTo investigate whether follicular fluid lipid-soluble micronutrients are associated with embryo morphology parameters during IVF.MethodsFollicle fluid and oocytes were obtained prospectively from 81 women. Embryo morphology parameter…

Little information is available on the intra-individual variability of oxidative stress biomarkers in healthy individuals and even less in the context of the menstrual cycle. The objective of this study was to characterize the analytical an…