Yasmyn E. Winstanley

Study questionIs oocyte developmental competence associated with changes in granulosa cell (GC) metabolism?Summary answerGC metabolism is regulated by the LH surge, altered by obesity and reproductive aging, and, in women, specific metaboli…

The female ovary contains a finite number of oocytes, and their release at ovulation becomes sporadic and disordered with aging and with obesity, leading to loss of fertility. Understanding the molecular defects underpinning this pathology …