BACKGROUND: Cancers of ductal origin often express glycoprotein mucin 1 (MUC1), also known as CA15.3, with higher levels leading to poor prognosis. Conversely, anti-MUC1 antibodies develop in some patients, leading to better prognosis. We s…
PurposeTo assess whether MUC1 peptide vaccine produces an immune response and prevents subsequent colon adenoma formation.Patients and methodsMulticenter, double-blind, placebo-controlled randomized trial in individuals age 40 to 70 with di…
Common 'themes' in epidemiology related to cancer risk beg a comprehensive mechanistic explanation. As people age, risk for cancer increases. Obesity and smoking increase the risk for many types of cancer. History of febrile childhood disea…
Endometriosis is a chronic inflammatory disorder defined as abnormal growth of endometrial tissue at ectopic sites, most often on the ovary. Women with endometriosis are at higher risk of developing ovarian cancer. We recently generated a m…