Hu Y

20(S)-protopanaxadiol (PPD), a dammarane-type aglycone generated from the intestinal metabolism of Panax ginseng saponins, has attracted increasing attention as a pharmacologically active natural compound. Over the past decade, accumulating…

Endometrial cancer (EC) incidence is rising, yet current diagnostics lack precision and scalability. We develop an artificial intelligence (AI)-based platform integrating multi-biofluid omics and clinical data for EC stratification. Using t…

Primary aldosteronism (PA) is associated with a substantially higher cardiovascular risk than essential hypertension, a disparity that cannot be fully explained by blood pressure elevation alone. Clinical studies consistently demonstrate th…

BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with both reproductive and metabolic dysregulation. While anti-Müllerian hormone (AMH) and the triglyceride-glucose (TyG) index have been independen…

BackgroundAfter early pregnancy loss (EPL), couples often seek counselling on how long to wait before attempting to conceive again. However, the optimal interpregnancy interval (IPI) between EPL and the next pregnancy is controversial. Addi…

Objective: To evaluate the efficacy and safety of triptorelin acetate microspheres for injection compared with triptorelin acetate for injection in the treatment of endometriosis. Methods: A total of 392 patients with endometriosis were pro…

OBJECTIVE: To evaluate the efficacy of intraoperative adhesion barriers in reducing long-term recurrence and alleviating pelvic pain in patients with endometriosis following laparoscopic surgery. METHODS: A retrospective analysis was perfo…

Yao Hu,1,* Yan Chen,1,* Gaolian Li,1 Qingjing Zou,1 Jiawei Zhan,2 Dongmei Li3 1Department of Obstetrics and Gynecology, Jingzhou Central Hospital, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People’s Republi…

BackgroundSyndrome differentiation in Traditional Chinese Medicine (TCM) is pivotal to clinical practice and dictates the efficacy of medicinal treatments. However, precision diagnostic models for TCM syndromes, constructed from biomarkers …

ObjectiveTo identify the risk factors for severe primary dysmenorrhea in adolescent girls and provide evidence for clinical prevention and intervention.MethodsThis retrospective study enrolled adolescent girls with primary dysmenorrhea from…

Endometriosis is a chronic estrogen-dependent disorder affecting up to 10% of women of reproductive age, and the absence of reliable noninvasive diagnostic tools contributes to delayed diagnosis and disease progression. To identify potentia…

BACKGROUND: Ovarian endometrioma (OEM) is a common manifestation of endometriosis and is associated with both local lesions and systemic alterations. While immune dysregulation and metabolic disturbances have been individually reported in e…

Endometriosis (EMs) is characterized by dysregulated persistence and enhanced invasiveness of ectopic endometrial cells. Current treatment strategies remain limited by high recurrence rates and considerable adverse effects. Although iron ov…

STUDY OBJECTIVE: To develop and validate a non-invasive, blood-based diagnostic assay for endometriosis that performs accurately across menstrual cycle phases and complements existing imaging modalities. DESIGN: Multicenter case-control st…

Gallbladder carcinoma, among the most prevalent malignancies of the biliary system, often presents with insidious early symptoms. Delayed diagnosis of incidental gallbladder carcinoma frequently leads to therapeutic delays, significantly co…

BACKGROUND: Carbohydrate antigen 19-9 (CA19-9) is a well-established tumour marker primarily associated with pancreaticobiliary and gastrointestinal malignancies. Its elevation in benign gynaecological conditions, particularly in isolated o…

BackgroundThis study aimed to analyze the clinical data within one year of the patients who underwent hysteroscopic endometrial polypectomy with levonorgestrel-releasing intrauterine system (LNG-IUS) insertion, and to identify the risk fact…

BackgroundNumerous studies have suggested that assessing endometrial and subendometrial blood flow can contribute to the evaluation of endometrial receptivity. However, there remains a lack of unified expert consensus regarding the assessme…

RESEARCH QUESTION: Do women with adenomyosis have altered uterine peristalsis, and can an objective and reproducible tool be developed to quantify uterine peristalsis on transvaginal sonography (TVS)? DESIGN: Prospective observational coho…

BackgroundEndometrial fibrosis can disrupt the uterine junctional zone and lead to infertility. Accurate and noninvasive evaluation of junctional zone alterations is important to clinical treatment. Although conventional T2-weighted imaging…

BACKGROUND: Adenomyosis (AM) is a common gynecological disorder in reproductive-age women, with impaired endometrial receptivity as a key contributor to infertility. However, a comprehensive single-cell atlas of the eutopic endometrium duri…

Endometriosis is a chronic gynecological disorder defined by the growth of endometrial-like tissue outside the uterus, driven by estrogen-dependent inflammation and progressive fibrosis. According to available data, remodeling and persisten…

The gut microbiota has been implicated in pulmonary vascular diseases, yet a direct causal link to pulmonary embolism (PE) remains unestablished. This study aimed to investigate the causal effects of gut microbiota on PE and to explore the …

ObjectivesTo evaluate the efficacy of Honghua Ruyi Pills combined with estradiol valerate and dydrogesterone tablets in promoting endometrial repair and menstrual recovery after artificial abortion.MethodsThis was a randomized, double-blind…

BACKGROUND: The SRU consensus on pelvic ultrasound proposed standardized augmented ultrasound, but its validity and indirect signs' role require validation. This study will explore the application value of this consensus in deep endometrios…