Nihel Ammous-Boukhris

ORCID: 0000-0002-5744-0328 · 2 papers in corpus

case-report 2026

A Novel BRCA1 Pathogenic Variant in Tunisian Patient With High Grade Ovarian Cancer: Favorable Therapeutic Response to Olaparib

Cancer reports (Hoboken, N.J.) ·doi:10.1002/cnr2.70658

BACKGROUND: Ovarian cancer is one of the leading causes of death from gynecological cancer worldwide. Genetic mutations in genes involved in key cellular functions such as BRCA1/2 play a central role in tumorigenesis and have major implicat…

case-report 2026

Unexpected double-hit BRCA1/BRCA2 somatic mutations in a sporadic endometrioid ovarian carcinoma

Molecular biology reports ·doi:10.1007/s11033-026-11598-0

BACKGROUND: Pathogenic variants in BRCA1 and BRCA2 are well known drivers of homologous recombination deficiency in ovarian carcinoma. Somatic BRCA mutations are observed in a minority of ovarian cancers. The co-occurrence of both BRCA1 and…