Zondervan, KT

About 10% of reproductive-age women have endometriosis. Symptoms can include severe pain, dysmenorrhea, dyspareunia, dysuria, infertility, and fatigue. The pathogenesis is unclear. Hormonal therapy controls symptoms in some women; others re…

Importance: Endometriosis is a chronic, estrogen-dependent, inflammatory disease defined by endometrial-like tissue (lesions) outside the uterine lining. It affects up to 10% of women worldwide, and 9 million women in the US, during reprodu…

Objective: To quantify the variation, triggers and impact on quality of life of symptom flares in women with chronic pelvic pain (CPP). Design: Cross-sectional questionnaire within the Translational Research in Pelvic Pain clinical cohort …

STUDY QUESTION Which classification system for endometriosis do clinicians use most frequently, and why? SUMMARY ANSWER Even with a high uptake of the three existing endometriosis classification systems, most clinicians managing endometrio…

目的 研究子宫内膜异位症发病的相关因素及其在中国和英国患者之间可能的差异。方法 采用病例对照研究方法，选取英国牛津John Radcliffe Hospital收治的子宫内膜异位症患者387例和非子宫内膜异位症患者199例、广州中医药大学第一附属医院收治的子宫内膜异位症患者101例和非子宫内膜异位症患者50例分别为病例组和对照组。通过标准化的WERF EPHect调查问卷，收集4组人群的身高、体质量、体质量指数、婚姻状况、工作状况、月经情况、生育情况、手术原因等临床资料并进行…

Study question Can a set of terms and definitions be prepared on endometriosis that would be the basis for standardization in disease description, classification and research? Summary answer The current paper outlines a list of 49 terms and…

Background: Different classification systems have been developed for endometriosis, using different definitions for the disease, the different subtypes, symptoms and treatments. In addition, an International Glossary on Infertility and Fert…

Background In the field of endometriosis, several classification, staging and reporting systems have been developed. However, endometriosis classification, staging and reporting systems that have been published and validated for use in clin…

The authors reply: The mainstay of current medical therapy for endometriosis is hormonebased and is thus predominantly contraceptive and nonteratogenic.Given that most cases of endometriosis occur during the reproductive years, the expected…

Endometriosis is a common inflammatory disease characterized by the presence of tissue outside the uterus that resembles endometrium, mainly on pelvic organs and tissues. It affects ~5–10% of women in their reproductive years — translating …

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and wa…

OBJECTIVE: To standardize the recording of surgical phenotypic information on endometriosis and related sample collections obtained at laparoscopy, allowing large-scale collaborative research into the condition. DESIGN: An international col…

We conducted a genome-wide association meta-analysis of 4,604 endometriosis cases and 9,393 controls of Japanese and European ancestry. We show that rs12700667 on chromosome 7p15.2, previously found to associate with disease in Europeans, r…

Endometriosis has a genetic component, and significant linkage has been found to a region on chromosome 10q. Two candidate genes, EMX2 and PTEN, implicated in both endometriosis and endometrial cancer, lie on chromosome 10q. We hypothesized…

The combined investigation of environmental and genetic risk-factors in complex traits will refocus attention on the case-control study. Endometriosis is an example of a complex trait for which most case-control studies have not followed th…